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Analysis of Osteocalcin Expression in Transgenic Mice Reveals a Species Difference in Vitamin D Regulation of Mouse and Human Osteocalcin Genes

✍ Scribed by Thomas L. Clemens; Hui Tang; Shigeto Maeda; Robert A. Kesterson; Francesco Demayo; J. Wesley Pike; Caren M. Gundberg


Book ID
111485941
Publisher
American Society for Bone and Mineral Research
Year
1997
Tongue
English
Weight
364 KB
Volume
12
Category
Article
ISSN
0884-0431

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Core binding factor alpha 1 (Cbfa1) is an osteoblast-specific transcription factor essential to develop a mature osteoblast phenotype. However, its exact role in the signaling of various osteotropic-differentiating agents is still unclear. In this study, we assessed the effects of 1,25-(OH)(2)-D3 (D