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Analysis of oncogenic AKT1 p.E17K mutation in carcinomas of the biliary tract and liver

✍ Scribed by Riener, M-O; Bawohl, M; Clavien, P-A; Jochum, W

Book ID: 109999592
Publisher: Nature Publishing Group
Year: 2008
Tongue: English
Weight: 45 KB
Volume: 99
Category: Article
ISSN: 0007-0920
DOI: 10.1038/sj.bjc.6604498

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## Abstract Somatic mutations of the __PIK3CA__ gene, which encodes the p110α catalytic subunit of phosphatidylinositol 3‐kinase (PI3K), are frequent in various cancer types. The majority of mutations cluster at hotspots within exons 9 and 20, which encode the helical and kinase domains of p110α. _