## Abstract Wilms tumor (WT) is genetically heterogeneous, and the one known WT gene, __WT1__ at 11p13, is altered in only a subset of WTs. Previous loss of heterozygosity (LOH) analyses have revealed the existence of additional putative WT genes at 11p15, 16q, and 1p, but these analyses examined o
Analysis of native WT1 protein from frozen human kidney and Wilms' tumors
β Scribed by Iben, Sebastian; Royer-Pokora, Brigitte
- Book ID
- 110062054
- Publisher
- Nature Publishing Group
- Year
- 1999
- Tongue
- English
- Weight
- 117 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0950-9232
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## Abstract We report expression of the __wt__ I (Wilms' tumor) gene by cultured human melanoma cells. Using RNA polymerase chain reaction analysis, __wt__ I transcripts were detected in 7 of 9 melanoma cell lines but not in 5 normal melanocyte strains. In Northern blot analysis, steadyβstate __wt_
## Abstract The Wilms' tumor 1 gene, __WT1__, encodes a zincβfinger protein that is implicated in the development of Wilms' tumor. Mutant or aberrantly expressed WT1 isoforms have also been described in desmoplastic small round cell tumor, acute leukemias, mesothelioma, breast tumors and melanoma.