Analysis of mutations induced by 4′-hydroxymethyl-4,5′,8-trimethylpsoralen and UVA in Escherichia coli lac Z gene and its regulatory region

Mutational specificities of environmenta

Mutational specificities of environmental carcinogens in the lacl Gene of Escherichia coli VII: The host-mediated assay and its comparison with in vitro mutagenesis induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone

✍ Jianli Jiao; Barry W. Glickman; Maria Zielenska; Joseph B. Guttenplan; Liu-Yu Xi 📂 Article 📅 1993 🏛 John Wiley and Sons 🌐 English ⚖ 430 KB

## Abstract To investigate the influence of different types of metabolic activation (9,000 x __g__ supernatant (S9) activation vs. a host‐mediated approach) on 4‐(methylnitrosamino)‐1‐(3‐pyridyl)‐1‐butanone (NNK)‐induced mutational specificity, we determined by DNA sequencing the distribution of fo