Assessing treatment–time interaction in
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F. Boutitie; F. Gueyffier; S. J. Pocock; J. P. Boissel
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Article
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1998
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John Wiley and Sons
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English
⚖ 178 KB
👁 3 views
Exploration of the variation of treatment effect over time in randomized clinical trials with low event rates is limited by lack of power. A meta-analysis on individual patient data from such trials can partly solve the problem, but brings other computational difficulties. Using an example in hypert