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Analysis of multiple failure time data from an AIDS clinical trial by Dianne M. Finkelstein, David A. Schoenfeld and Eva Stamenovic, Statistics in Medicine, 16, 951–961 (1997)

✍ Scribed by Cédric Mahé

Publisher
John Wiley and Sons
Year
1998
Tongue
English
Weight
50 KB
Volume
17
Category
Article
ISSN
0277-6715

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✦ Synopsis

have presented recently an interesting paper on the way to analyse AIDS clinical trials when we have a combined endpoint of infection recurrences and death. They use one of the most famous multivariate generalizations of the proportional hazards model: the model of Wei, Lin and Weissfield (hereafter referred as WLW). They explore, in the framework of a clinical trial of prophylaxis for fungal infections, several applications of this model for the analysis of effect of treatment for prevention of infection and death. First, they consider each of several different types of opportunistic infections, then the recurrence of a type of infection. These analyses show how interpretations implied by the way of handling the data are complex, even when the model is chosen. Let us take advantage of this to make some intuitive but questioning comments:

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ANALYSIS OF MULTIPLE FAILURE TIME DATA F
ANALYSIS OF MULTIPLE FAILURE TIME DATA FROM AN AIDS CLINICAL TRIAL
✍ DIANNE M. FINKELSTEIN; DAVID A. SCHOENFELD; EVA STAMENOVIC 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 205 KB 👁 2 views

The primary endpoint of AIDS prophylaxis trials is the occurrence of opportunistic infections. While the treatments are not expected to have an effect on the underlying HIV disease, an effect of treatments on mortality cannot be ruled out. Therefore, the primary analysis of these trials must be base