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Analysis of microsatellite instability and hypermutation of immunoglobulin variable genes in Werner syndrome

✍ Scribed by Karli Rosner; David B. Winter; Gunhild Lange Skovgaard; Junko Oshima; Patricia J. Gearhart; Vilhelm A. Bohr

Book ID: 114096038
Publisher: Elsevier Science
Year: 2001
Tongue: English
Weight: 326 KB
Volume: 122
Category: Article
ISSN: 0047-6374
DOI: 10.1016/s0047-6374(01)00256-1

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## Abstract Somatic hypermutation of immunoglobulin (Ig) genes plays a critical role in the maturation of the human antibody response. The molecular basis of this important process is, however, unknown. To identify __cis__‐acting sequences that initiate and target hypermutation, we have made three