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Analysis of Ligand Binding and Protein Dynamics of Human Retinoid X Receptor Alpha Ligand-Binding Domain by Nuclear Magnetic Resonance †

✍ Scribed by Lu, Jianyun; Cistola, David P.; Li, Ellen


Book ID
127340673
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
960 KB
Volume
45
Category
Article
ISSN
0006-2960

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## Abstract The effect of retinoid X receptor (RXR) antagonists on the conformational exchange of the RXR ligand‐binding domain (LBD) remains poorly characterized. To address this question, we used nuclear magnetic resonance spectroscopy to compare the chemical shift perturbations induced by RXR an