Analysis of Ki-ras, p53, and MDM2 Genes in Uterine Leiomyomas and Leiomyosarcomas
โ Scribed by Kevin L. Hall; Michael G. Teneriello; Robert R. Taylor; Stephen Lemon; Masahito Ebina; R.Ilona Linnoila; J.Henry Norris; Robert C. Park; Michael J. Birrer
- Book ID
- 115617162
- Publisher
- Elsevier Science
- Year
- 1997
- Tongue
- English
- Weight
- 622 KB
- Volume
- 65
- Category
- Article
- ISSN
- 0090-8258
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The aim of this study is to address the role of mdm-2-gene amplification in the tumorigenesis of uterine sarcomas. Differential PCR with DNA from formalin-fixed paraffin-embedded specimens was employed in 12 patients with uterine sarcomas. We detected mdm-2-gene amplification in 4 out of 12 uterine
Uterine leiomyomas are the most prevalent tumor type in women of reproductive age and are the most common reason for hysterectomies. Although uterine leiomyomas are considered to be benign, they are a major public health concern for women. In contrast, leiomyosarcomas are rare but highly malignant u