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Analysis of Identity, Charge Variants, and Disulfide Isomers of Monoclonal Antibodies with Capillary Zone Electrophoresis in an Uncoated Capillary Column

✍ Scribed by He, Yan; Lacher, Nathan A.; Hou, Weiying; Wang, Qian; Isele, Colleen; Starkey, Jason; Ruesch, Margaret


Book ID
127298353
Publisher
American Chemical Society
Year
2010
Tongue
English
Weight
740 KB
Volume
82
Category
Article
ISSN
0003-2700

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Rapid analysis of charge variants of mon
✍ Yan He; Colleen Isele; Weiying Hou; Margaret Ruesch 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 191 KB 👁 1 views

## Abstract A capillary zone electrophoresis (CZE) method was developed for the rapid analysis of charge heterogeneity of immunoglobulin G (IgG) monoclonal antibodies (mAbs). The separation was carried out in a short, dynamically coated fused‐silica capillary. A number of separation parameters were