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Analysis of human kallikrein 7 expression as a potential biomarker in cervical neoplasia

✍ Scribed by Lara Termini; Paulo Cesar Maciag; Fernando Augusto Soares; Suely Nonogaki; Sônia Maria Miranda Pereira; Venâncio Avancini Ferreira Alves; Adhemar Longatto-Filho; Luisa Lina Villa

Publisher
John Wiley and Sons
Year
2010
Tongue
French
Weight
373 KB
Volume
127
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Overexpression of kallikrein 7, a proteolytic enzyme important for epithelial cell shedding, may be causally involved in carcinogenesis, particularly in tumor metastasis and invasion. In this study, we have evaluated hK7 (human kallikrein 7) protein levels by immunohistochemistry in 367 cervical histological samples including 35 cases of cervicitis, 31 low‐grade cervical intraepithelial neoplasia, 51 high‐grade cervical intraepithelial neoplasia (H‐SIL), 197 squamous cervical carcinomas (SCC) and 53 cervical adenocarcinomas. We have observed that hK7 staining increased with the severity of cervical disease. Intense hK7 staining was found in 15.2% of cervicitis samples, in contrast to 55% of H‐SIL and 68% of SCC. Moreover, 92.5% of adenocarcinomas also exhibited intense hK7 staining. Differences in the expression of hK7 could potentially be used as a biomarker for the characterization of different stages of cervical disease.

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