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Analysis of HSV isolated from patients with unilateral and bilateral herpetic keratitis

✍ Scribed by M. Tognon; R. Manservigi; A. Sebastiani; G. Bragliani; M. Busin; E. Cassai

Publisher
Springer Netherlands
Year
1985
Tongue
English
Weight
420 KB
Volume
8
Category
Article
ISSN
0165-5701

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✦ Synopsis

Restriction enzyme analysis was utilized to investigate 11 HSV isolates from patients with herpetic keratitis. The electrophoretic profiles of the DNAs indicate that the isolates belong to HSV-1 and are epidemiologically unrelated. Two of the isolates, derived from a patient with simultaneous bilateral herpetic keratitis were further characterized by genetic and phenotypic analyses. These studies showed the following: (i) the two recrudescent lesions were caused by the same HSV-1 isolate; (ii) the isolate yielded two different plaque phenotypes; (iii) these plaques showed different sensitivity to I.D.U.

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