𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Analysis of HLA-DRB1 alleles in Japanese patients with chronic myelogenous leukemia

✍ Scribed by Yasukawa, Masaki; Ohminami, Hideki; Kojima, Kensuke; Inokuchi, Koiti; Nishimura, Yasuharu; Fujita, Shigeru

Publisher
John Wiley and Sons
Year
2000
Tongue
English
Weight
23 KB
Volume
63
Category
Article
ISSN
0361-8609

No coin nor oath required. For personal study only.

✦ Synopsis

To clarify the association between HLA-DRB1 alleles and chronic myelogenous leukemia (CML), the HLA-DRB1 allele frequencies in 50 Japanese patients each with b2a2 and b3a2 CML and 127 healthy Japanese individuals were examined. In the patients with b2a2 CML, the frequencies of HLA-DRB1*0405, DRB1*08032, and DRB1*1502 were low and that of HLA-DRB1*1201 was high in comparison with the healthy individuals. The frequencies of HLA-DRB1*0403, DRB1*0802, DRB1*1403, and DRB1*1405 were high, and those of HLA-DRB1*08032 and DRB1*1501 were low in the patients with b3a2 CML. The present results suggest positive and negative associations between certain HLA-DRB1 alleles and CML.

πŸ“œ SIMILAR VOLUMES

Hydroxyurea-Induced gangrene of the toes
Hydroxyurea-Induced gangrene of the toes in a patient with chronic myelogenous leukemia
✍ Yasuda, Norimasa; Ohmori, Sei-ichi; Usui, Tadao πŸ“‚ Article πŸ“… 2000 πŸ› John Wiley and Sons 🌐 English βš– 148 KB πŸ‘ 2 views

To the Editor: Semenzato et al. proposed new criteria for large granular lymphocyte (LGL) leukemia because patients with low levels of GL were similar to those with levels greater than 2,000 GL/l [1]. LGL leukemia is a GL proliferative disease often accompanied by pure red cell aplasia (PRCA). T-cel