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Analysis of HLA class I expression in progressing and regressing metastatic melanoma lesions after immunotherapy

✍ Scribed by Rafael Carretero; José M. Romero; Francisco Ruiz-Cabello; Isabel Maleno; Felix Rodriguez; Francisco M. Camacho; Luis M. Real; Federico Garrido; Teresa Cabrera

Book ID: 105947926
Publisher: Springer-Verlag
Year: 2008
Tongue: English
Weight: 413 KB
Volume: 60
Category: Article
ISSN: 0093-7711
DOI: 10.1007/s00251-008-0303-5

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## Abstract Loss of HLA class I expression on tumor cells is a frequent event as an immune escape mechanism. Seven different altered HLA phenotypes have been defined in tumors. Various molecular mechanisms have been described as responsible for HLA class I loss. HLA class I expression alterations o