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Analysis of heparin sodium by SAX/HPLC for contaminants and impurities

✍ Scribed by Michael L. Trehy; John C. Reepmeyer; Richard E. Kolinski; Benjamin J. Westenberger; Lucinda F. Buhse


Book ID
108189608
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
352 KB
Volume
49
Category
Article
ISSN
0731-7085

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Four hexasaccharides representing major structural sequences of heparin were isolated and characterized after degradation of heparin by heparinase. The structures were determined from two-dimensional 1H NMR spectroscopy including TOCSY (total correlated spectroscopy), COSY (correlated spectroscopy),