Analysis of growth rate effects on productivity of recombinant Escherichia coli populations using molecular mechanism models

The effect of heating rate on Escherichi

The effect of heating rate on Escherichia coli metabolism, physiological stress, transcriptional response, and production of temperature-induced recombinant protein: A scale-down study

✍ Luis Caspeta; Noemí Flores; Néstor O. Pérez; Francisco Bolívar; Octavio T. Ramír 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 270 KB 👁 2 views

## Abstract At the laboratory scale, sudden step increases from 30 to 42°C can be readily accomplished when expressing heterologous proteins in heat‐inducible systems. However, for large scale‐cultures only slow ramp‐type increases in temperature are possible due to heat transfer limitations, where