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Analysis of Flavin Oxidation and Electron-Transfer Inhibition in Plasmodium falciparum Dihydroorotate Dehydrogenase †

✍ Scribed by Malmquist, Nicholas A.; Gujjar, Ramesh; Rathod, Pradipsinh K.; Phillips, Margaret A.

Book ID: 127381344
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 274 KB
Volume: 47
Category: Article
ISSN: 0006-2960
DOI: 10.1021/bi702218c

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## Abstract Triclosan, a well‐known inhibitor of Enoyl Acyl Carrier Protein Reductase (ENR) from several pathogenic organisms, is a promising lead compound to design effective drugs. We have solved the X‐ray crystal structures of __Plasmodium falciparum__ ENR in complex with triclosan variants havi