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Analysis of deoxyribonucleotide pools in human cancer cell lines using a liquid chromatography coupled with tandem mass spectrometry technique

✍ Scribed by Wei Zhang; Shenglan Tan; Elijah Paintsil; Ginger E. Dutschman; Elizabeth A. Gullen; Edward Chu; Yung-Chi Cheng


Book ID
113489512
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
691 KB
Volume
82
Category
Article
ISSN
0006-2952

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## Abstract Gemcitabine triphosphate (dFdCTP) is a highly active metabolite of gemcitabine. It is formed intra‐cellularly via the phosphorylation of gemcitabine by deoxycytidine kinase. The monitoring of dFdCTP in human peripheral blood mononuclear cells (PBMCs), in addition to plasma concentration