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Analysis of cyclophosphamide and carboxyethylphosphoramide mustard enantiomers in human plasma and application to clinical pharmacokinetics

✍ Scribed by Castro, Francine Attié de; Scatena, Gabriel dos Santos; Cass, Quézia Bezerra; Simões, Belinda Pinto; Lanchote, Vera Lucia


Book ID
127070102
Publisher
Elsevier Science
Year
2014
Tongue
English
Weight
507 KB
Volume
971
Category
Article
ISSN
1873-376X

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Determination of cyclophosphamide enanti
✍ Carolina De Miranda Silva; Bruno Jose Dumêt Fernandes; Maria Paula Marques Perei 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 170 KB

## Abstract This article describes the enantioselective analysis of cyclophosphamide (CPA) in human plasma using LC‐MS/MS. CPA enantiomers were extracted from plasma using a mixture of ethyl acetate and chloroform (75:25, v/v). The enantiomers were separated on a Chiralcel® OD‐R column, with the mo