Analysis of Colony-Forming Ability of Human Fibroblast Strains by Linear Regression

✍ Scribed by Lutz Edler; Heinz Walter Thielmann

• Book ID: 102759120
• Publisher: John Wiley and Sons
• Year: 1987
• Tongue: English
• Weight: 895 KB
• Volume: 29
• Category: Article
• ISSN: 0323-3847
• DOI: 10.1002/bimj.4710290710

✦ Synopsis

1

A linear regression approach is presented for the statistical analysis of dose-response curves obtained by measuring the colony-forming ability of human fibroblast strains. The crucial determination of the dose range in which the linear model can be assumed is achieved by a combination of statistical criteria and biological claims. As a basic quantitative parameter we investigate the slope of the regression line and, by taking reciprocals, we retransform i t into the biologically established parameter D,,. Several methods for the combination of estimates are presented.