Analysis of chromosome 7 in adult and pediatric ependymomas using chromogenicin situhybridization
โ Scribed by Mariarita Santi; Martha Quezado; Rubin Ronchetti; Elisabeth J. Rushing
- Book ID
- 106480149
- Publisher
- Springer US
- Year
- 2005
- Tongue
- English
- Weight
- 271 KB
- Volume
- 72
- Category
- Article
- ISSN
- 0167-594X
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Ependymomas are glial tumors of the brain and spinal cord occurring both sporadically and in a familial syndrome, neurofibromatosis type 2 (NF2). Previous analyses performed on specimens obtained predominantly from adult patients have shown loss of DNA sequences from chromosome arm 22q, which is the
## Abstract Previous studies on childhood germ cell tumors (GCTs) report highly variable frequencies of losses at chromosome arm 1p. Since deletions at 1p portend a poor prognosis in other embryonal tumors, this study aims to clarify the question of the frequency of true allelic loss at 1p and whet