Analysis of cell populations of normal and injured mouse lens epithelium. II. Contribution of local and migrating cells to wound healing

✍ Scribed by Rafferty, Nancy S.

• Publisher: John Wiley and Sons
• Year: 1976
• Tongue: English
• Weight: 489 KB
• Volume: 186
• Category: Article
• ISSN: 0003-276X
• DOI: 10.1002/ar.1091860109

✦ Synopsis

Abstract

The contribution of progenitor cells in the normal peripheral region of mouse lens epithelium to healing of a centrally located wound was studied using an autoradiographic technique designed to follow migrating ^3^H‐thymidine labeled cells. It was found that few progenitor cells labeled before or at the time of injury migrate toward the wound and hence contribute little to the repair of the wound. Moreover, the central injury did not delay or reverse the normal migration of the labeled peripheral cells in the opposite direction into the bow. It is concluded from this and other studies that a central injury to the mouse lens is healed mainly by numerous local cells which are stimulated for the most part to traverse one replicative cycle of normal duration, and that the injury does not affect formation of new lens fibers. These findings are thought to be related to the observed low incidence of traumatic cataract in the mouse.