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Analysis of buprenorphine and its n-dealkylated metabolite in plasma and urine by selected-ion monitoring

✍ Scribed by Ylva Blom; Ulf Bondesson; Erik Änggård

Publisher
Elsevier Science
Year
1985
Weight
584 KB
Volume
338
Category
Article
ISSN
0378-4347

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A highly sensitive and specific quantitative assay for metoprolol and two of its metabolites, containing an unchanged 2-hydroxy-4-isopropylaminopropoxy sidechain, has been developed. The compounds are isolated from the alkalized sample (plasma or urine) by extraction with dichloromethane, and conver