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Analysis of aristolochic acids in herbal medicines by LC/UV and LC/MS

✍ Scribed by Ming-Chung Lee; Chi-Hsiang Tsao; Song-Chou Iou; Wu-Chang Chuang; Shuenn-Jyi Sheu

Publisher
John Wiley and Sons
Year
2003
Tongue
English
Weight
722 KB
Volume
26
Category
Article
ISSN
1615-9306

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✦ Synopsis

Abstract

Two high‐performance liquid chromatographic methods, one combined with a photodiode array detector (LC/UV) and another with mass spectrometry (LC/MS), were developed for the analysis of aristolochic acid I and II in herbal medicines. The LC/UV method was carried out using a Cosmosil 5C18‐MS column with a gradient solvent system composed of phosphate buffer‐acetonitrile and a UV detector (390 nm). The LC/MS method was performed using an acetate buffer‐acetonitrile solvent system and positive‐ion electrospray ionization MS. The characteristic fragment ions for aristolochic acid I were selected at m/z 359, m/z 324, m/z 298, and m/z 296, and for aristolochic acid II at m/z 329, m/z 294, and m/z 268. In order to attain better resolution, solid phase extraction was used to prepare the test solution in this study.

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