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Analysis of Antiplatelet Effect of Ticlopidine In Humans: Modeling Based on Irreversible Inhibition of Platelet Precursors in Bone Marrow

✍ Scribed by Masataka Katashima; Yasuhiko Yamada; Koujirou Yamamoto; Hajime Kotaki; Hitoshi Sato; Yasufumi Sawada; Tatsuji Iga

Book ID: 110402785
Publisher: Springer
Year: 1999
Tongue: English
Weight: 714 KB
Volume: 27
Category: Article
ISSN: 1573-8744
DOI: 10.1023/a:1020995013200

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## Abstract In this study, we investigated the effect of the long‐term (10 days) application of a defined and uniform level of fluid flow (uniform shear stress of 1.2 × 10^−3^ N/m^2^) on human bone marrow stromal cells (BMSC) cultured on different substrates (i.e., uncoated glass or calcium phospha