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Analysis of a newly-isolated temperature sensitive maternal effect mutation ofDrosophila melanogaster

โœ Scribed by Fausto-Sterling, Anne ;Weiner, Amy J. ;Digan, Mary Ellen

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
930 KB
Volume
200
Category
Article
ISSN
0022-104X

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โœฆ Synopsis

Abstract

A mutation located near the tip of the X chromosome in Drosophila melanogaster has been isolated, and its developmental effects described. This mutation (1(1)tsโ€1) is temperature sensitive, and at permissive temperature (18ยฐC) develops normally. However, zygotes from females raised or aged at restrictive temperature (28ยฐC) never hatch, regardless of the embryonic genotype. Midgut formation is abnormal in lethal zygotes and dorsal closure is probably incomplete. Temperature shift experiments have shown that the zygotic lethality is governed by a temperature sensitive period in oocytes of stage seven or older. If viable 1(1)tsโ€1 embryos are shifted to restrictive temperatures, they develop as far as the pupal stage, but never eclose. The temperature sensitive period for pupal lethality includes the last 2.5 days of pupal development and does not involve a maternal effect.

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