✦ LIBER ✦
Analysis of 13C NMR substituent chemical shifts in some (aryl)(2-nitrobenzo [b]thiophen-3-yl)amines: A new class of compounds with analgesic, anti-exudative and anti-inflammatory activities showing low mutagenicity
✍ Scribed by Liliana Lamartina; Domenico Spinelli; Francesco Guerrera; Maria Concetta Sarvà
- Publisher
- John Wiley and Sons
- Year
- 1995
- Tongue
- English
- Weight
- 448 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0749-1581
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✦ Synopsis
Abstract
The ^13^C NMR chemical shift values of (aryl)(2‐nitrobenzo[b]thiophen‐3‐yl)amines were measured in DMSO‐d~6~ solutions, suggesting the occurrence of an alternate charge polarization at C‐3, C‐2, C‐3a, C‐7a, C‐4 and C‐5. A dual substituent parameter analysis of the experimental data indicates a large or a low resonance contribution for aryl para or meta substituents, respectively, while the inductive component remains constant throughout.