Quality measurement, control, and improvement in combinatorial chemistry
Combinatorial chemistry has developed rapidly in the past decade, with great advances made by scientists working on analysis and purification of a large number of compounds and the analysis of polymer-bound compounds. However, formidable challenges lie ahead of today's researcher. For example, high-throughput analysis and purification technologies must be further developed to ensure combinatorial libraries are "purifiable," and "drugable."
To this end, Analysis and Purification Methods in Combinatorial Chemistry describes various analytical techniques and systems for the development, validation, quality control, purification, and physicochemical testing of combinatorial libraries. A new volume in Wiley's Chemical Analysis series, this text has four parts covering:
* Various approaches to monitoring reactions on solid support and optimizing reactions for library synthesis
* High-throughput analytical methods used to analyze the quality of libraries
* High-throughput purification techniques
* Analytical methods applied in post-synthesis and post-purification stages
Drawing from the contributions of respected experts in combinatorial chemistry, this comprehensive book provides coverage of applications of Nuclear Magnetic Resonance (NMR), liquid chromatography/mass spectrometry (LC/MS), Fourier Transform Infrared (FTIR), micellar electrokinetic chromatography (MEKC) technologies, as well as other analytical techniques.
This eminently useful volume is an essential addition to the library of students and researchers studying or working in analytical chemistry, combinatorial chemistry, medicinal chemistry, organic chemistry, biotechnology, biochemistry, or biophysics.Content:
Chapter 1 Quantitative Analysis in Organic Synthesis with NMR Spectroscopy (pages 1โ36): Laura H. Lucas and Cynthia K. Larive
Chapter 2 19F Gel?Phase NMR Spectroscopy for Reaction Monitoring and Quantification of Resin Loading (pages 37โ51): Joseph M. Salvino
Chapter 3 The Application of Single?Bead FTIR and Color Test for Reaction Monitoring and Building Block Validation in Combinatorial Library Synthesis (pages 53โ69): Jason J. Cournoyer, Clinton A. Krueger, Janice V. Wade and Bing Yan
Chapter 4 HR?MAS NMR Analysis of Compounds Attached to Polymer Supports (pages 71โ86): Meritxell Guino and Yolanda R. de Miguel
Chapter 5 Multivariate Tools for Real?Time Monitoring and Optimization of Combinatorial Materials and Process Conditions (pages 87โ123): Radislav A. Potyrailo, Ronald J. Wroczynski, John P. Lemmon, William P. Flanagan and Oltea P. Siclovan
Chapter 6 Mass Spectrometry and Soluble Polymeric Support (pages 125โ135): Christine Enjalbal, Frederic Lamaty, Jean Martinez and Jean?Louis Aubagnac
Chapter 7 High?Throughput NMR Techniques for Combinatorial Chemical Library Analysis (pages 137โ173): Ting Hou and Daniel Raftery
Chapter 8 Micellar Electrokinetic Chromatography as a Tool for Combinatorial Chemistry Analysis: Theory and Applications (pages 175โ208): Peter J. Simms
Chapter 9 Characterization of Split?Pool Encoded Combinatorial Libraries (pages 209โ252): Jing Jim Zhang and William L. Fitch
Chapter 10 Strategies and Methods for Purifying Organic Compounds and Combinatorial Libraries (pages 253โ280): Jiang Zhao, Lu Zhang and Bing Yan
Chapter 11 High?Throughput Purification: Triage and Optimization (pages 281โ306): Jill Hochlowski
Chapter 12 Parallel HPLC in High?Throughput Analysis and Purification (pages 307โ320): Ralf God and Holger Gumm
Chapter 13 Organic Compound Stability in Large, Diverse Pharmaceutical Screening Collections (pages 321โ350): Kenneth L. Morand and Xueheng Cheng
Chapter 14 Quartz Crystal Microbalance in Biomolecular Recognition (pages 351โ368): Ming?Chung Tseng, I?Nan Chang and Yen?Ho Chu
Chapter 15 High?Throughput Physicochemical Profiling: Potential and Limitations (pages 369โ406): Bernard Faller
Chapter 16 Solubility in the Design of Combinatorial Libraries (pages 407โ434): Christopher Lipinski
Chapter 17 High?Throughput Determination of Log D Values by LC/MS Method (pages 435โ455): Jenny D. Villena, Ken Wlasichuk, Donald E. Schmidt and James J. Bao