Analysis and prediction of protein β-sheet structures by a combinatorial approach
✍ Scribed by Cohen, Fred E.; Sternberg, Michael J. E.; Taylor, William R.
- Book ID
- 109718734
- Publisher
- Nature Publishing Group
- Year
- 1980
- Tongue
- English
- Weight
- 552 KB
- Volume
- 285
- Category
- Article
- ISSN
- 0028-0836
- DOI
- 10.1038/285378a0
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The unfolding dynamics of cellular retinoic acid-binding protein I (CRABP I), an 18 kDa predominantly b-sheet protein, were studied by monitoring the hydrogen-deuterium (H-D) exchange reaction under various solution conditions. A bimodal charge state distribution was observed when a denaturing agent
## Abstract The genome sequences of numerous organisms are available now, but gene sequences alone do not provide sufficient information to accurately deduce protein functions. Protein function is largely dependent on the association of multiple polypeptide chains into large structures with interac