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Analyses of hla linkage in white families with multiple cases of seropositive rheumatoid arthritis

✍ Scribed by Rodney C. P.Go; Graciela S. Alarcón; Ronald T. Acton; William J. Koopman; Virginia J. Vittor; Bruce O. Barger


Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
784 KB
Volume
30
Category
Article
ISSN
0004-3591

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## Abstract ## Objective Cytotoxic T lymphocyte–associated antigen 4 (CTLA‐4) is a negative regulator of T cells and is, therefore, a strong candidate susceptibility gene for T cell–mediated autoimmune diseases. The association of CTLA‐4 single‐nucleotide polymorphisms (SNPs) with rheumatoid arthr