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Analyses of clinicopathological, molecular, and prognostic associations ofKRAScodon 61 and codon 146 mutations in colorectal cancer: cohort study and literature review

✍ Scribed by Imamura, Yu; Lochhead, Paul; Yamauchi, Mai; Kuchiba, Aya; Qian, Zhi; Liao, Xiaoyun; Nishihara, Reiko; Jung, Seungyoun; Wu, Kana; Nosho, Katsuhiko; Wang, Yaoyu E; Peng, Shouyong; Bass, Adam J; Haigis, Kevin M; Meyerhardt, Jeffrey A; Chan, Andrew T; Fuchs, Charles S; Ogino, Shuji


Book ID
125400719
Publisher
BioMed Central
Year
2014
Tongue
English
Weight
350 KB
Volume
13
Category
Article
ISSN
1476-4598

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## Abstract A cyclin‐dependent kinase inhibitor CDKN2A (p16/Ink4a) is a tumor suppressor and upregulated in cellular senescence. CDKN2A promoter methylation and gene silencing are associated with the CpG island methylator phenotype (CIMP) in colon cancer. However, prognostic significance of CDKN2A