The in vivo and ex vivo distributions and the pharmacological profile of the fluorinated phenylpiperazine derivative p-[ 18 F]MPPF (4-(2Π-methoxyphenyl)-1-[2Π-(N-2Π-pyridinyl)-p-fluorobenzamido]-ethylpiperazine) were evaluated in the cat brain as a potential selective antagonist for 5-HT 1A receptor
Analogues of WAY 100635 as radiotracers for in vivo imaging of 5-HT1A receptors
β Scribed by Alan A. Wilson; Armando Garcia; Jin Li; Jean N. Dasilva; Sylvain Houle
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- French
- Weight
- 441 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0022-2135
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Positron emission tomography (PET), following an intravenous injection of [carbonyl-(11)C]WAY 100635, was used to image central 5-HT(1A) receptors in rat following pretreatment with graded doses of (-)-pindolol (0.001-3 mg/kg, i.v.). The use of PET had advantages over ex vivo radioligand binding met
## Abstract 5βHT~1A~ receptors are involved in a variety of psychiatric disorders and __in vivo__ molecular imaging of the 5βHT~1A~ status represents an important approach to analyze and treat these disorders. We report herein the synthesis of three new fluoroethylated 5βHT~1A~ ligands (AH1.MZ, AH2
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