Analogues of arginine vasopressin and its agonist and antagonist modified in the N-terminal part of the molecule with l-beta-homophenylalanine
✍ Scribed by Sobolewski, D. ;Kowalczyk, W. ;Prahl, A. ;Derdowska, I. ;Slaninova, J. ;Zabrocki, J. ;Lammek, B.
- Book ID
- 110893858
- Publisher
- John Wiley and Sons
- Year
- 2005
- Tongue
- English
- Weight
- 116 KB
- Volume
- 65
- Category
- Article
- ISSN
- 1397-002X
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## Abstract The present work is part of our studies aimed at clarifying the influence of steric constraints in the __N__‐terminal part of arginine vasopressin (AVP) and its analogs on the pharmacological activity of the resulting peptides. We describe the synthesis of eight new analogs of AVP or [3
## Abstract Using SPPS techniques, six new analogues of AVP and some of its agonists were synthesised. The peptides were designed by substitution of Phe at position 3 of AVP, [Mpa^1^] AVP (dAVP) and [Mpa^1^,Val^4^,D‐Arg^8^]VP (dVDAVP) with L‐ or D‐Pip, a non‐coded α‐imino acid, also called homoprol