Analogs of carbamyl aspartate as inhibitors of dihydroorotase: preparation of boronic acid transition-state analogs and a zinc chelator carbamylhomocysteine

Synthesis and Evaluation of Optical 2-Be

Synthesis and Evaluation of Optical 2-Benzyl-5-bromo-4-oxopentanoic Acids as Transition-state Analog Inhibitors against Carboxypeptidase A

✍ Jing-Yi JIN; Shou-Feng WANG; Wei XUAN; Ji-Wen SHENG; Si-Hong WANG; Guan-Rong TIA 📂 Article 📅 2008 🏛 John Wiley and Sons 🌐 English ⚖ 117 KB 👁 1 views

## Abstract Both enantiomers of 2‐benzyl‐5‐bromo‐4‐oxopentanoic acid were prepared utilizing the diazo ketones as the key intermediates. The compounds were assayed for inhibitory activity against carboxypeptidase A (CPA, EC 3.4.17.1). The (__R__)‐form is 260‐fold more potent than the corresponding