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Analgesics of the 6,14-ethenomorphinan type. 6-Deoxy-7.alpha.-orvinol and 6-deoxy-8.alpha.-orvinol

✍ Scribed by Knipmeyer, Laura L.; Rapoport, Henry


Book ID
125977316
Publisher
American Chemical Society
Year
1985
Tongue
English
Weight
907 KB
Volume
28
Category
Article
ISSN
0022-2623

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## Abstract The anion **5** of thebaine (**1**) reacts with small electrophiles exclusively at the 5‐position (__Schemeβ€…1__). Reaction of thebaine anion with a range of alkylarylsilyl chlorides showed that reaction at the 7‐position was favored with increasing steric bulk, with triphenylsilyl chlor