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Analgesic effect of acetaminophen-codeine combination in mice

✍ Scribed by Dr. Françoise Hertz; Michèle Ranson; Romano Deghenghi


Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
303 KB
Volume
6
Category
Article
ISSN
0272-4391

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We have studied the hypoalgesic effect of codeine (100 mg) after blocking the hepatic O-demethylation of codeine to morphine via the sparteine oxygenase (CYP2D6) by quinidine (200 mg). The study was performed in 16 extensive metabolizers of sparteine, using a double-blind, randomized, four-way, cros