The effect of quinidine on the analgesic
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S. H. Sindrup; L. Arendt-Nielsen; K. Brøsen; P. Bjerring; H. R. Angelo; B. Eriks
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Article
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1992
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Springer
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English
⚖ 514 KB
We have studied the hypoalgesic effect of codeine (100 mg) after blocking the hepatic O-demethylation of codeine to morphine via the sparteine oxygenase (CYP2D6) by quinidine (200 mg). The study was performed in 16 extensive metabolizers of sparteine, using a double-blind, randomized, four-way, cros