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Analgesic and Thermic Effects, and Cerebrospinal Fluid and Plasma Pharmacokinetics, of Intracerebroventricularly Administered Morphine in Normal and Sensitized Rats

✍ Scribed by HEMENDRA N. BHARGAVA; VINCENT M. VILLAR; JULIO CORTIJO; ESTEBAN J. MORCILLO


Book ID
118111194
Publisher
Pharmaceutical Press
Year
1998
Tongue
English
Weight
612 KB
Volume
50
Category
Article
ISSN
2042-7158

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## Abstract The aim of this study was to investigate the pharmacokinetic behavior of huperzine A (Hup A) in plasma and cerebrospinal fluid (CSF) after intranasal administration (0.5 mg/kg) in male Sprague‐Dawley rats. A pharmacokinetic study of intravenous Hup A (0.5 mg/kg) was also performed. The