Analgesic and Antiinflammatory Effects of the Tannin Fraction from Myracrodruon urundeuva Fr. All.

✍ Scribed by G. S. B. Viana; M. A. M. Bandeira; L. C. Moura; M. V. P. Souza-Filho; F. J. A. Matos; R. A. Ribeiro

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 90 KB
• Volume: 11
• Category: Article
• ISSN: 0951-418X
• DOI: 10.1002/(sici)1099-1573(199703)11:2<118::aid-ptr38>3.0.co;2-j

✦ Synopsis

The present work showed a significant antinociceptive activity in the tannin fraction (TF) extracted from the bark of Myracrodruon urundeuva Fr. All. This inhibitory effect was demonstrated not only against abdominal contractions but also in the formalin test in mice. In the first case, at doses of 0.1 and 1 mg/kg, i.p. the TF caused inhibitions of the order of 39.6% and 80.8%, respectively, and in the second one, inhibitions of 47.8% and 77.2% (phase I) and 59.2% and 100% (phase II), after the administration of 5 and 10 mg/kg, i.p. The antinociceptive effect was partially reverted by naloxone. The TF presented also an antioedematogenic effect in rat paw oedema induced by carrageenan as well as dextran. In the carrageenan model, significant inhibitions were seen at 2 h (29.7% and 41.7%) and 3 h (40.5% and 44.2%), after administration of 5 and 10 mg/kg, i.p. In the dextran induced oedema, the TF (10 mg/kg, p.o.) caused inhibitions of 29.2%, 42.4% and 54.5% at 2 h, 3 h and 4 h, respectively. The TF (10 and 25 mg/kg, i.p.) significantly inhibited the inflammatory events (vesical oedema and increased vascular permeability) which occur at the onset of the haemorrhagic cystitis induced by cyclophosphamide. After subcutaneous or oral administration, the TF (5-50 mg/kg) also blocked neutrophil migration induced by direct (fMLP) as well as indirect (carrageenan) stimuli.