An unusual reaction to opioid blockade with naltrexone in a case of post-traumatic stress disorder

✍ Scribed by Paloma Ibarra; Stephen P. Bruehl; Charles R. Carlson; John F. Wilson; Jane A. Norton; James A. McCubbin; Thomas B. Montgomery

• Publisher: Springer
• Year: 1994
• Tongue: English
• Weight: 385 KB
• Volume: 7
• Category: Article
• ISSN: 0894-9867
• DOI: 10.1002/jts.2490070210

✦ Synopsis

An unusual behavioral and cardiovascular reaction was observed during opioid blockade with naltrexone in a 32-year-old male who met DSM 111-R criteria f o r post-traumatic stress disorder (PTSD). As part of an ongoing placebo-controlled investigation of the effects of naltraone on laboratory and ambulatory blood pressure reactivity, this participant reported experiencing feelings of rage, explosive behavior, and other unpleasant symptoms. When compared to all other subjects (N = 24), this individual showed significantly greater effects of naltraone on blood pressure reactivity during the laboratory stressor. His ambulatory blood pressures, when compared to placebo, were significantly increased during the 24-hr period following naltrexone. The unusual behavioral and cardiovascular responses following ingestion of naltraone suggest an important role for endogenous opioids in adjustment to stress in this case of PTSD.