An Unusual Factor Influencing Action of Some Drugs on Smooth Muscle

Presence of epidermal growth factor rece

Presence of epidermal growth factor receptors and influence of epidermal growth factor on proliferation and aging in cultured smooth muscle cells

✍ Girija Bhargava; Leonard Rifas; Maynard H. Makman 📂 Article 📅 1979 🏛 John Wiley and Sons 🌐 English ⚖ 744 KB

## Abstract Epidermal growth factor (EGF) at nanomolar concentrations stimulated DNA synthesis in confluent, serum‐starved cultures of calf aorta and human uterine smooth muscle cells. Stimulation of DNA synthesis in lens epithelial cells was studied for comparison. L and D‐ascorbic acid potentiate