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An unusual case of cyclin-D1-positive peripheral T cell lymphoma with a 11:14 translocation

โœ Scribed by Helen Mary Alexander; Elizabeth Young; Lorna W. Harries; Miles Joyner; Paul Newman; Patrick Sarsfield


Book ID
107648069
Publisher
Springer-Verlag
Year
2010
Tongue
English
Weight
489 KB
Volume
3
Category
Article
ISSN
1865-5785

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Multiple myeloma (MM) frequently shows overexpression of cyclin D1, either due to a t(11;14)(q13;q32) translocation, or in association with polysomy 11. The predominant expression of a cyclin D1 mRNA isoform lacking the 3'-untranslated region (Delta3'UTR) is associated with higher total cyclin D1 mR