An unusual association: vulval schistosomiasis, microinvasive vulval squamous cell carcinoma and high-grade vulval intraepithelial neoplasia in HIV patient

High frequency of loss of heterozygosity

High frequency of loss of heterozygosity in vulval intraepithelial neoplasia (VIN) is associated with invasive vulval squamous cell carcinoma (VSCC)

✍ Adam N. Rosenthal; Andy Ryan; Deborah Hopster; Thirunavukarasu Surentheran; Ian 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 French ⚖ 90 KB 👁 2 views

Vulval intraepithelial neoplasia (VIN) is thought to be the premalignant phase of human papillomavirus (HPV)-associated vulval squamous cell carcinoma (VSCC). Various molecular events have been suggested as markers for progression from VIN to VSCC, but loss of heterozygosity (LOH) in vulval neoplasi