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An unexpected reversal of stereochemistry in a modification of the rychnovsky cyanohydrin alkylation

โœ Scribed by Linda Joy Brzezinski; Dinah D. Levy; James W. Leahy


Book ID
108380180
Publisher
Elsevier Science
Year
1994
Tongue
French
Weight
286 KB
Volume
35
Category
Article
ISSN
0040-4039

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An Unexpected Result in the Alkylation o
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A moderate yield(55%)preparation ofN-1substituted thyminehasbeenachievedbyreacting an excess of 4-bromobutylacetate at 100 "C for 48 brs. N-1, N-3 bisall@atedand O-alkylated compounds werealsoobtained as by-products. 0 1997Published byElsevierScienceLtd.