✦ LIBER ✦
An unexpected high frequency of trisomic fetuses in 229 pregnancies monitored for advanced maternal age
✍ Scribed by E. S. Sachs; M. G. J. Jahoda; M. F. Niermeijer; H. Galjaard
- Publisher
- Springer
- Year
- 1977
- Tongue
- English
- Weight
- 194 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0340-6717
No coin nor oath required. For personal study only.
✦ Synopsis
In 229 pregnancies monitored because of advance maternal age, 16 (7%) abnormal fetal karyotypes were detected. We found 13 cases of trisomy 21, twice a trisomy 18, and once an additional marker chromosome. The frequency of abnormal fetal karyotypes in different maternal age groups was found to increase from 1:20 at 38--40 years, to 1:16 at 41--43 years, and finally to 1:4.5 in women of 44--46 years. The overall incidence of chromosomal aberrations and specifically of trisomy 21 is considerably higher than that described in retrospective studies.