✦ LIBER ✦

An outbreak of hepatitis a in an institution for the mentally retarded

✍ Scribed by Pieter J. Helmsing; Willem Duermeyer; Frits Wielaard; Gerard C.A.M. van Hattem

Publisher: John Wiley and Sons
Year: 1980
Tongue: English
Weight: 467 KB
Volume: 5
Category: Article
ISSN: 0146-6615
DOI: 10.1002/jmv.1890050208

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

From December 1977 until April 1978 a hepatitis A outbreak occurred in an institution for the mentally retarded. The institution housed 311 residents and had a staff of 308. The outbreak was studied by enzyme‐linked immunosorbent assays for hepatitis A antigen and antibodies, and by liver function tests in serum.

When the investigations started, 13 residents and one staff member were ill and already seropositive; 34 of the 182 residents that were seronegative at that time and 1 2 of the 223 seronegative staff members subsequently developed disease. Out of the 60 eases 32 were asymptomatic; 19 cases with jaundice were seen.

Normal human immunoglobulin was administered to a large part of the seronegative group, but the effect is difficult to interpret as the immunoglobulin was often given after the presumed time of infection and failed to protect. Elevated liver enzyme levels were demonstrated in 38 of 60 patients.

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