An open label trial of raclopride in acute schizophrenia. Confirmation of D2-dopamine receptor occupancy by PET
β Scribed by L. Farde; F. -A. Wiesel; P. Jansson; G. Uppfeldt; A. Wahlen; G. Sedvall
- Publisher
- Springer
- Year
- 1988
- Tongue
- English
- Weight
- 723 KB
- Volume
- 94
- Category
- Article
- ISSN
- 0033-3158
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The eect of acute oral ethanol intake (1 . 0 g/kg) on cerebral D2-receptors ([ 11 C]raclopride binding) was studied in seven healthy volunteers, using water and alcohol in two separate 59-min PET sessions. In the alcohol experiments, the blood ethanol concentration at the beginning of the imaging wa
The selective D2-dopamine receptor antagonist raclopride and its pharmacologically inactive (R)-enantiomer FLB472 were labelled with 11C and used in a study with positron emission tomography to examine the stereoselectivity of 11C-raclopride binding to central D2-dopamine receptors in three healthy