β Scribed by J. Reglinski; M. Al-Kabban; W.E. Smith; I.D. Watson; M.J. Stewart
No coin nor oath required. For personal study only.
An NMR model for the study of drug interactions with solid tumour is described. It is based on the use of packed cells in a simple medium. The system is capable of dealing with cellular biochemistry at a molecular level through experiments conducted in a homogeneous field by 1H spin-echo NMR spectroscopy. However, through a simple imaging technique, it is also possible to introduce a spatial element into the chemistry of the packed cells. The use of these complementary NMR methods are illustrated by the action of the cytotoxic agent doxorubicin on cellular glycolysis. A pattern of signals observed in a homogeneous field experiment following oxidative stress are duplicated in the imaging experiment to illustrate the toxins' ability to penetrate the model tumour.
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A model IS proposed to predict the transient reactlon temperature and extent of reactlon for a sohd decomposltlon m terms ofphyslcal transport coefficients and thermodymamlcdata. allowmg also tor the effect of changing particle size arIsIng from possible density differences between reactant and prod