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An iterative procedure for differential analysis of gene expression

✍ Scribed by Avner Bar-Hen; Stéphane Robin

Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
82 KB
Volume
337
Category
Article
ISSN
1631-073X

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✦ Synopsis

Microarrays are a popular technology to study genes that are differentially expressed between two conditions. In this Note, we propose an iterative procedure to determine the biggest subset of non-differentially expressed genes. We prove a pseudo Markov relationship that allows practical computations. We obtain explicit expressions for FDR and the level of the proposed test at each step.

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Elucidation of the changes in gene expression associated with biological processes is a central problem in biology. Advances in molecular and computational biology have led to the development of powerful, high-thoughput methods for the analysis of differential gene expression. These tools have opene