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An Iterative Acetylene–Epoxide Coupling Strategy for the Total Synthesis of Aspinolide A

✍ Scribed by Gowravaram Sabitha; Teega Rammohan Reddy; Chitti Srinivas; Jhillu Singh Yadav


Publisher
John Wiley and Sons
Year
2011
Tongue
German
Weight
150 KB
Volume
94
Category
Article
ISSN
0018-019X

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✦ Synopsis


Abstract

The total synthesis of aspinolide A (1) was successfully achieved by an iterative acetyleneepoxide coupling strategy and a Yamaguchi lactonization as the key steps.


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An iterative strategy for the synthesis
✍ Thomas Pinault; Frédéric Chérioux; Bruno Therrien; Georg Süss-Fink 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 107 KB

## Abstract An iterative strategy for the synthesis of new sulfur‐functionalized oligothiophenes by Suzuki or Stille cross‐coupling reactions was applied to the reaction of 4‐bromo‐tert‐butylphenylthioether with thiophene derivatives. The planarity of the oligothiophenes obtained was confirmed by t