An ion-exchange method for the detection of amides, imides and anilides

✍ Scribed by Philip W. West; Mohsin Qureshi; Saidul Zafar Qureshi

• Publisher: Elsevier Science
• Year: 1966
• Tongue: English
• Weight: 555 KB
• Volume: 36
• Category: Article
• ISSN: 0003-2670
• DOI: 10.1016/0003-2670(66)80010-7

✦ Synopsis

Aligarlr (India)

(Rcccived January I 5th. I gGG)

A number of tests are available for the detection of amides and imides. Amides have been detected by the hydroxamic acid test in the presence of nitriles, esters, acid anhydrides, acid chlorides or trichloromethyl groupingi-and in the presence of nitriles alone by the soda lime-methanolic copper sulphate tcstJ. The mercury(H) chloride-bromothymol blue test" is useful for the differentiation between nitriles and amides, but it is unreliable in the presence of crotonaldehydc, acetone, cyclopentanone, z,+-pentadione, diethyl malonate, ethylacetoacetate, vinyl acetate, phenol, some carboxylic acids and alkynes. The presence of olefinic or acetylenic multiple bonds or or-hydrogen atoms also invalidates the test.

The simplest approach to the problem appears to bc to hydrolyze the compound and to detect the presence of the ammonium ions or aniline so produced, by the specific tests available for them. FEIGL~ developed